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About Olis GlobalWorks™
Global analysis of kinetic and equilibrium data produces better results1; often, in fact, global analysis makes the difference between correct and incorrect conclusions2.
Fueled by the invention of a scanning spectrophotometer capable of producing 1,000 spectral scans per second3 and admonished by the pioneering kineticist, Professor Quentin H. Gibson4 to "pity the poor scientist who must deal with all the data your machine will vomit at him5", Drs. Richard J. DeSa and Iain B.C. Matheson developed one method after the other6 to resolve the thousands of millisecond snapshots into a meaningful set of starting, final, and intermediate species.
The program produced by Matheson and DeSa employs Singular Value Decomposition, Downhill Simplex, and Matrix Exponentiation. The near decade long development of this program has culminated in an instantaneously fast and extremely easy to use fitting software package which allows the experimentalist to fit kinetic and equilibrium 3D, allowing correct conclusions to be made from multidimensional data (time, temperature, concentration) in seconds.
Today's Olis GlobalWorks is the combined effort of Olis, Inc. and Evolution Software Design, Inc. to create the best 3D data handling and fitting software package in the world. The software includes an ever expanding selection of supported kinetic and equilibrium models (nearly 50 are incorporated already) and a linkable module for acquiring data from a host of spectrophotometric equipment, including, but not limited to the Olis RSM 1000, Olis DSM CD Spectrophotometers, Olis Upgraded Spectrometers, and others.
Olis GlobalWorks ...Because Global Works Better!
... Now, with Secondary Structure Determination Algorithms, too!
Footnotes
1) Beecham, Joseph M, and Brand, Ludwig, "Global Analysis of Fluorescence Decay: Applications to Some Unusual Experimental and Theoretical Studies," Photochemistry and Photobiology Vol 44., No. 3, pp 323-329, 1986.
2) Time Resolved Spectra: The Difference Between Correct and Not
3) US Patent #5,285,254 granted on February 8, 1994 to Richard J. DeSa for Rapid-Scanning Monochromator with Moving Intermediate Slit.
4) Dr. Quentin J. Gibson is a chaired professor emeritus at Cornell and Rice Universities; and co-author with RJD of 1969 paper: DeSa, R. J., and Gibson, Q. H., "A Practical Automatic Data Acquisition System for Stopped-Flow Spectrophotometry," Computers and Biochemical Research 2, 494-505 (1969).
5) Personal communication between DeSa and Gibson, 1992-3.
6) Matheson, I. B. C., "The Method of Successive Integration: A General Technique for Recasting Kinetic Equations in a Readily Soluble Form Which Is Linear in the Coefficients and Sufficiently Rapid for Real Time Instrumental Use," Analytical Instrumentation, 16(3), 345-373 (1987).
View a list of equations supported by Olis GlobalWorks for fitting up to five species.
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